ABSTRACT
OBJECTIVE: The effects of fetal growth of lipid metabolism in pregnancy are not well understood at present. The aim of this study was to perform a cross sectional study of lipid and lipidprotein concentrations in the 3rd trimester, from normal pregnancies and those complicated by intrauterine growth restriction pregnancies (IUGR) without preeclampsia. METHODS: Fasting blood samples for lipid and lipidprotein fractions were taken 3rd trimester. from fourty two women with IUGR; fourty five women with uncomplicated pregnancies matched as a group for age, parity, gestational age and fetal body weight. RESULTS: Total cholesterol (6.74+/-1.14 mmol/L vs 4.23+/-1.03 mmol/L, P<0.01), triglyceride 2.10+/-0.95 mmol/L vs 2.42+/-0.73 mmol/L. P<0.05) and LDL (3.41+/-0.83 mmol/L vs 4.23+/-1.07 mmol/L, P<0.01) concentrations were significantly lower in the IUGR group than in normal group. Free fatty acid (0.8+/-0.21 mmol/L vs 0.5+/-0.01 mmol/L, P<0.01) concentration, ApoB/ApoA ratio (0.86+/-0.42 vs 0.77+/-0.47, P<0.01). HDL/ApoA (0.87+/-0.1 vs 0.72+/-0.05, P<0.05) ratio were significantly higher in the IUGR group than in normal group. There were no difference in other lipids. CONCLUSION: The results of this study suggest that LDL levels, which normally increase in uncomplicated pregnancies, fail to rise appropriately in pregnancies complicated by IUGR and may play a role in the pathogenesis of fetal growth restriction. Change in ApoA and increased ApoB/ApoA ratio may be used in identifying mothers with, or at risk of, a pregnancy complicated by IUGR.
Subject(s)
Female , Humans , Pregnancy , Apolipoproteins A , Cholesterol , Fasting , Fetal Development , Fetal Growth Retardation , Gestational Age , Lipid Metabolism , Lipoproteins , Mothers , Parity , PlasmaABSTRACT
Spontaneous rupture of symphysis pubis during delivery is rare condition. The overall incidence is 1/600~1/30000 deliveries. The Separation was associated with considerable pain, swelling and tenderness over the symphysis pubis and confirmed roentgenographically. The condition was treated conservatively with bed rest, mostly in the lateral decubitus position, aided by a restrictive pelvic binder. Mobilization was initiated after pain relieved. Recovery can be expected to be complete. We present a case of spontaneous rupture of symphysis pubis during delivery with a brief review of the literature.
Subject(s)
Bed Rest , Incidence , Rupture , Rupture, SpontaneousABSTRACT
No abstract available.
Subject(s)
Female , Humans , Insulin , Lipoproteins , Pregnant Women , TriglyceridesABSTRACT
The single enzyme P-450c17 hydroxylase catalyzes the 17a-hydroxylation of both pregnenolone and progesterone and the side-chain cleavage of 17a-hydroxypregnenolone and 17a-hydroxypro- gesterone to dehydroepiandrosterone and androstenedione. This enzyme is located in the endoplasmic reticulum and consists of a P-450c17 and a specific flavoprotein NADPH-cytochrome P-450 reductase. The clinical picture and hormonal pattern in 17a-hydroxylase deficiency have been consistent in both genotypic sexes with hypergonadotropic hypogonadism in whom the virtual absence of gonadal steroids results in a female phenotype with primary amenorrhea and pseudohermaphro- ditism in the male and underdeveloped secondary sex characteristics and hypermineralocorticoidism with hypertension, hypokalemia, suppressed renin-angiotensin system and extremely reduced aldo-sterone production. A 17-year-old girl visited endocrine clinic because of amenorrhea, absence of pubic and axillary hair, and hypertension. she had elevated levels of serum corticosterone, deoxycorticosterone(DOC), 18-hydroxycorticosterone(18-OHB). Stumulation with ACTH effected minimal increase in the elevated steroids and the ACTH-stimulated 18-OHB to aldosterone ratio was more than 280. These hormonal patterns appear to be homozygote in 17a-hydroxylase deficiency.